Ascalix Syrup 4g/30ml
1. NAME OF THE MEDICINAL PRODUCT
Ascalix Syrup 4g/30ml
Piperazine Citrate equivalent to Piperazine Hydrate BP 4g/30ml
The oral treatment of roundworm infestation.
Treatment of Roundworm._
Take by mouth the following dose once only:_
Adults and Children over 8 years 30ml (the contents of the bottle) Children 3 to 8 years 20ml (four 5ml spoonfuls)
Children 1 to 2 years 10ml (two 5ml spoonfuls)
Ascalix is not recommended for children under 1 year.
Sensitivity to piperazine, renal failure or previous history of epilepsy. Moderate to severe hepatic impairment.
Use with caution in patients with severe malnutrition and anaemia. In ascariasis, if the patient has normal bowel movements, a purgative is not necessary but if patient is constipated, it is necessary to purge the patient about 12 hours after treatment so that the worms are expelled before the effects of the drug wears off.
It may potentiate the extrapyramidal effects in patients receiving phenothiazines. Pyrantel pamoate antagonises the modes of action of piperazine and therefore should not be co-administered.
Piperazine should not be given at any time during pregnancy except on medical advice.
In the recommended dosage side-effects are not common but the following have been reported:
Drowsiness, confusion, ataxia, reduced muscle tension Clonic contractions have occurred but are only likely if neurological abnormalities or renal disease exist. Abdominal cramps, headaches, dizziness, tremors, choreirform movements, hyporeflexia, nystagmus, seizures, blurred vision, paralytic strabismus and rarely, cataracts.
Allergic reactions occasionally encountered include:
Skin reactions, arthralgia, fever, oedema and tachycardia. Urticaria, photodermatitis, erythema multiforme, purpura, eczematous skin reactions, lacrimation, rhinorrhoea and rarely, broncospasm.
The symptoms of overdose are likely to be as in Undesirable effects (4.8).
Ensure adequate fluid intake and adopt supportive measures according to symptoms. Gastric lavage is only useful if piperazine ingestion is very recent
Administer anti-convulsants if indicated.
Piperazine is an anthelmintic effective against roundworm and threadworm. In roundworms piperazine produces muscle paralysis and the worms are then expelled with the faeces.
Piperzine affects all stages of roundworm in the gut. The mode of action of piperazine on threadworm is not fully understood.
Piperazine is readily absorbed from the gastro-intestinal tract and is excreted in the urine partially as degraded products.
There is a wide variation in the rate at which piperazine is excreted by different individuals.
Sucrose, Glycerin, Sodium Saccharin, Hydroxybenzoates (Methyl, Ethyl Propyl and Butyl), Propylene Glycol, Flavouring (Malaga Raisin Essence, Morella Cherry Essence), Caramel (E150) and Water.
Store in a cool place.
30ml Beatson Clarke Winchester.
No special instructions required.
Wallace Manufacturing Chemists Ltd.
Wallace House 51-53 Stert Street Abingdon
Oxfordshire OX14 3JF United Kingdom
06 April 1973, 19 April 1994