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210 mm

TnToYmation for the user

Thrush Oral Capsule and Cream Duo

(Fluconazole, Clotrimazole)

f Talk to your pharmacist or doctor:

•    If this is the first time you have had these symptoms

•    If you have had thrush more than twice in the last 6 months

•    If you are under 16 years, or 61 years or older

•    If you or your partner have been exposed to a sexually transmitted disease

•    If you have liver disease, or have had unexplained jaundice (yellowing of the skin and eyes)

•    If you have kidney problems

•    If you have heart problems, including heart rhythm problems, or abnormal levels of potassium, magnesium or calcium in your blood

•    If you have AIDS (you may be more likely to experience skin reactions)

•    If you have any other long-term illness, or receive regular treatment from your doctor

•    If you are taking any other medicines, except for the contraceptive “pill” (see "If you use other medicines" on the back of the leaflet)

•    If you have lower stomach pain, or pain or a burning sensation on passing urine

•    If you are unsure about the cause of your symptoms

•    If you are a man and:

-    Your sexual partner does not have thrush

-    You have an abnormal discharge or leakage from your penis

-    You have sores, ulcers or blisters on your penis

-    Your penis has started to smell

•    If you are a woman and:

-    You have any abnormal or irregular vaginal bleeding, or a blood stained discharge

-    You have sores, ulcers or blisters on your vulva or vagina

Other important information

Pregnancy: mis medicine should not be used if you are pregnant, or if you think you may be pregnant.

Women of childbearing age: You must use a reliable form of contraception when using this medicine. The ingredients in the cream, however, may affect the latex used in barrier contraceptives such as condoms and diaphragms.

You should therefore use other methods of contraception whilst using this medicine and for at least 5 days after last using the cream.

Breastfeeding: This medicine should not be used if you are breastfeeding.

Driving and using machines: This medicine is not expected to affect your ability to drive or use machines. However, the medicine may cause dizziness and occasionally fits or other side effects that may affect you. You should not drive or use machines until you are sure you are not affected.

Cetyl alcohol and stearyl alcohol in the cream may cause local skin reactions (e.g. contact dermatitis).

Treating thrush: You can help the treatment to work if you follow these simple self-help tips:

•    Although the infected area will itch, do not scratch as this will damage the surface of the skin and cause the infection to spread further

•    Keep the affected areas of skin clean

•    Pay particular attention to drying the skin but avoid excessive rubbing

To help prevent thrush from coming back once you have treated it, follow these simple steps:

•    Wash daily. Try to avoid washing with perfumed soaps or using vaginal deodorants

•    Do not rub hard with sponges or flannels and avoid hot baths with strong perfumed oils

•    Wear cotton underwear and loose fitting clothing. Try to avoid wearing tights, nylon underwear and tight fitting clothing

•    After going to the toilet, wipe yourself from the front to the back, as a thrush infection may be transferred from the bowel

•    Change your sanitary protection regularly    4

IT you use other medicines

You should not use this medicine if you are taking certain medicines (see “Do not take”). This medicine may also affect the way other medicines work.

You should talk to your pharmacist if you are taking ANY other medicines, particularly if you are taking any of the following medicines:

•    Medicines that thin your blood (e.g. warfarin)

•    Rifabutin or rifampicin (for bacterial infections)

•    Medicines to reduce cholesterol (e.g. statins)

•    Medicines for mental health conditions (tricyclic antidepressants, e.g. amitriptyline, nortriptyline), or for epilepsy (e.g. carbamazepine or phenytoin)

•    Methadone (for pain relief or treatment of opioid dependence)

•    Fentanyl, alfentanil, or non-steroidal anti-inflammatory medicines (for pain relief or inflammation)

•    Medicines for diabetes

•    Amphotericin B, voriconazole (for fungal infections)

•    Ciclosporin, everolimus, sirolimus, or tacrolimus (given after transplant surgery, or for psoriasis or rheumatism)

•    Medicines to help you sleep (benzodiazepines, e.g. midazolam, triazolam), or for anxiety

•    Medicines for high blood pressure (e.g. nifedipine, losartan)

•    Medicines for treating cancer (e.g. cyclophosphamide or vinca alkaloids)

•    Prednisone (a corticosteroid)

•    Zidovudine or saquinavir (for HIV infection)

•    Theophylline (for asthma)

•    Vitamin A

Any other medicines includes medicines prescribed by your doctor and medicine you have bought for yourself, including herbal and homeopathic remedies.

/How to use this medicine

Check the capsule foil is not broken before use. If it is, do not take the capsule.

Check the cream tube seal is not broken before first use. If it is, do not use the cream.

Pierce tube seal with end of cap.

Age	How much	How often
Adults aged 16 to 60 years	Capsule: One capsule.	Once only.
	Cream: Apply a thin layer to the affected area.	Two or three times a day for 2 weeks.

Swallow the capsule with water.

The cream is for use on the skin only. For women, apply the cream to the vulva and surrounding area. For men, apply the cream to the penis.

Do not use for children under 16 years, or if you are an adult of 61 years or older, unless your doctor tells you to.

Do not use more than the amount recommended above.

If symptoms do not go away within 7 days talk to your doctor.

If symptoms clear up but then return after 7 days, you can take another capsule, unless you had an allergic reaction the first time.

If you have thrush more than twice in six months you must see your doctor.

f If you accidentally take a large number of capsules, or accidentally swallow some of the cream: Talk to a doctor or go to your nearest hospital casualty department straight away. Take your medicine and this leaflet with you.

Possible side effects

Most people will not have problems, but some may get some:

! If you get any of these serious side effects, stop using the medicine. See a doctor at once:

•    Difficulty breathing, swelling of the face, neck, tongue or throat, low blood pressure, fainting (severe allergic reactions that may be caused by the capsule or the cream)

•    Severe skin rash which may include peeling and blistering of the skin (caused by the capsule)

You must not take fluconazole again if you experience any of these serious side effects.

The capsule may also cause these serious side effects. See a doctor at once if you notice:

•    Liver problems such as yellowing of the skin or eyes, dark coloured urine, pale stools, or changes in the way your liver works (that may show up in blood tests)