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Co-Amilofruse 5mg/40mg Tablets

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Blood tests

Frumil Tablets can change the levels of liver enzymes or body fats known as cholesterol and triglycerides shown up on blood tests.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.qov.uk/vellowcard By reporting side effects you can help provide more information on the safety of this medicine.

5. Howto store Frumil Tablets

Keep out of the sight and reach of children Do not take your Frumil Tablets after the expiry date which is stated on the carton and blister label after ‘Exp’. The expiry date refers to the last day of that month.

Do not store above 25°C.

Keep the blister strip in the outer carton in order to protect from light and moisture.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Procured from within the EU and repackaged by the Product Licence holder: B&S Healthcare, Unit 4, Bradfield Road, Ruislip, Middlesex,

HA4 0NU.UK.

This leaflet does not contain all the information about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist.

Frumil 40mg/5mg Tablets PL No: 18799/2403

Leaflet date: 20.05.2015

Frumil is a registered trademark of Sanofi.

6. Further Information


What Frumil Tablets contain

The active substance is furosemide and amiloride hydrochloride.

Each tablet contains 40mg furosemide and 5mg amiloride hydrochloride.

The other ingredients are lactose monohydrate, maize starch, microcrystalline cellulose, sodium starch glycolate, sunset yellow (E110), talc, colloidal anhydrous silica and magnesium stearate.

What Frumil Tablets look like and contents of the pack

Frumil Tablets are orange, evenly mottled circular tablets with bevel edges and ‘FRUMIL’ embossed on one side, with a breakline on the other.

Frumil Tablets are available in calendar blister packs containing 28 tablets.


Frumil 40mg/5mg Tablets

(furosemide / amiloride hydrochloride)

Read all of this leaflet carefully before you start

taking this medicine

•    Keep this leaflet. You may need to read it again

•    If you have any further questions, ask your doctor or pharmacist

•    This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours

•    If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist

In this leaflet:

1.    What Frumil Tablets are and what they are used for

2.    Before you take Frumil Tablets

3.    Howto take Frumil Tablets

4.    Possible side effects

5.    Howto store Frumil Tablets

6.    Further information

1. What Frumil Tablets are and what they are used for

What Frumil Tablets are

The name of your medicine is Frumil 40mg/5mg Tablets (called Frumil Tablets throughout this leaflet). Frumil Tablets contain two different medicines called: furosemide and amiloride hydrochloride. Both belong to a group of medicines called diuretics (water tablets).

What Frumil Tablets are used for

Frumil Tablets can be used to stop the build up of extra water in your body. This extra water can cause swollen ankles, shortness of breath and feeling more tired than usual.

How Frumil Tablets work

Frumil Tablets work by helping you to pass more water (urine) than you usually do. If the extra water in your body is not removed, it can put extra strain on the heart, blood vessels, lungs, kidneys or liver.

x You are allergic to sulphonamides such as sulfadiazine or co-trimoxazole x You have severe problems with your kidneys x You have severe liver problems x Your doctor has told you that you have a low blood volume or are dehydrated x You are not passing any water (urine) x You have too much or too little potassium or sodium in your blood (shown in blood tests) x You have an illness called ‘Addison’s Disease’.

This can make you feel tired and weak, x You are breast-feeding (see “Pregnancy and breast-feeding” section below) x You are taking other medicines which change the amount of potassium in your blood (see “Taking other medicines” section below) x If the person taking the medicine is under 18 years. Frumil Tablets are not suitable for children

Do not take Frumil Tablets if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Frumil Tablets.

Take special care with Frumil Tablets

Check with your doctor or pharmacist before

taking your medicine if:

▲    You have difficulty in passing water (urine)

▲    You are 65 years of age or older

▲    You have liver or kidney problems

▲    You are an elderly patient with dementia and are also taking risperidone

▲    You have diabetes

▲    You have low blood pressure or feel dizzy when you stand up

▲    You have prostate problems

▲    You have gout

▲    You feel dizzy or dehydrated. This can happen if you have lost a lot of water through being sick, having diarrhoea or passing water very often. It can also happen if you are having trouble drinking or eating

▲    You are going to have a glucose test

▲    You are taking any other water tablets

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Frumil Tablets.

2. Before you take Frumil Tablets

Do not take this medicine and tell your doctor if:

You are allergic (hypersensitive) to furosemide, amiloride hydrochloride or any of the other ingredients of Frumil Tablets (listed in Section 6)

Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue

Taking other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you buy without a prescription, including herbal medicines. This is because Frumil Tablets can affect the way some other medicines work.

Also, some medicines can affect the way Frumil Tablets work.


Do not take this medicine, and tell your doctor,

if you are taking:

•    Medicines which change the amount of potassium in your blood. These include potassium supplements such as potassium chloride or certain water tablets (diuretics) such as triamterene

The following medicines can affect the way

Frumil Tablets work and increase the chance of

you getting side effects:

•    Medicines such as ramipril, enalapril, perindopril (called ‘ACE inhibitors’) or losartan, candesartan, irbesartan (called ‘angiotensin II receptor antagonists’). Your doctor may need to change the dose of your tablets or ask you to stop taking them

•    Medicines for high blood pressure or heart problems. Your doctor may need to change the dose of your medicine

•    Medicines used as a general anaesthetic for relaxing your muscles during surgery

•    Medicines for diabetes. These may not work as well when you are taking Frumil Tablets.

•    Theophylline - used for wheezing or difficulty in breathing

•    Phenytoin - used for epilepsy. This can lower the effect of Frumil Tablets

The following medicines can increase the

chance of side effects when taken with Frumil

Tablets:

•    Lithium - used for mental illnesses. To help stop side effects your doctor may need to change the dose of your lithium and check the amount of lithium in your blood.

•    Cisplatin - used for some cancers

•    Digoxin - used for heart problems. Your doctor may need to change the dose of your medicine.

•    Non-steroidal anti-inflammatory drugs (NSAIDS) - used for pain and inflammation such as aspirin, ibuprofen, ketoprofen or indometacin

•    Carbamazepine - used for epilepsy

•    Aminoglutethimide - used for breast cancer

•    Ciclosporin - used to stop the rejection of organs after a transplant

•    Methotrexate - used for cancers of the skin, joint or bowel diseases

•    Carbenoxolone - used for ulcers of the foodpipe (gullet)

•    Reboxetine - used for depression

•    Amphotericin - used for fungal infections if used fora long time

•    Corticosteroids - used for inflammation such as prednisolone

•    Liquorice - often used in cough medicines if taken in large amounts

•    Probenecid (used with another HIV medicine)

•    Medicines for infection such as gentamicin, amikacin, neomycin, netilmicin, tobramycin, vancomycin or high doses of cephalosporins

•    Medicines used as injections before X-ray examinations

•    Medicines used for constipation (laxatives) if used for a long time such as bisacodyl or senna

•    Medicines for asthma when given in high doses such as salbutamol, terbutaline sulphate, salmeterol, formoterol orbambuterol

•    Other water tablets (diuretics) such as bendroflumethiazide. Your doctor may need to change the dose of your medicine

Pregnancy and breast-feeding

Do not take Frumil Tablets if you are pregnant. Talk to your doctor before taking this medicine if you are pregnant, might become pregnant, or think you might be pregnant.

Do not breast-feed if you are taking Frumil Tablets. This is because small amounts may pass into the mother’s milk. Talk to your doctor before taking this medicine if you are breast-feeding or planning to breast-feed.

Ask your doctor or pharmacist for advice before taking any medicine if you are pregnant or breastfeeding.

Driving and using machines

You may feel dizzy or unwell after taking Frumil Tablets. If this happens, do not drive or use any tools or machines.

Important information about some of the

ingredients of Frumil Tablets

This medicine contains:

•    A colour called ‘sunset yellow’ (E110). This may cause allergic reactions.

•    Lactose. If you have been told by your doctor that you cannot tolerate some sugars, talk to your doctor before taking this medicine.

3. How to take Frumil Tablets

Always take Frumil Tablets exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

Taking this medicine

•    Take this medicine by mouth

•    Swallow the tablets whole with a drink of water

•    If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor

How much Frumil Tablets to take

The usual dose is one or two tablets first thing in the morning. Your doctor will tell you how many tablets to take.

If you are taking sucralfate (a medicine for stomach ulcers)

Do not take sucralfate at the same time as Frumil Tablets. Take your dose at least 2 hours before or after Frumil Tablets. This is because it can affect the way your medicine works.

If you take more Frumil Tablets than you should

If you think you may have taken more Frumil Tablets than you should, or if a child has swallowed any of your tablets, tell your doctor or got to your nearest hospital casualty department straight away. Remember to take with you any medicine that is left so the doctor knows what you have taken.

The following effects may happen: dry mouth, feeling thirsty, muscle pain or cramps, feeling sick or being sick (vomiting), weak or uneven heartbeat, feeling dizzy, weak or sleepy.

If you forget to take Frumil Tablets

If you forget a dose, take it as soon as you remember it. Then continue the following morning as normal. Do not take a double dose to make up for a forgotten dose.

If you stop taking Frumil Tablets

Keep taking Frumil Tablets until your doctor tells you to stop taking it.

Blood tests

Your doctor may carry out blood tests to check that the levels of some salts in the blood are at the correct levels.

rn

If you have any further questions onthe use of this product, ask your doctoror pharmacist.

4. Possible side effects

Like all medicines, Frumil Tablets can cause side effects, although not everybody gets them.

Tell a doctor straight away if you notice any of the following serious side effects - you may need urgent medical treatment

•    If you have an allergic reaction. The signs may include inflammation of the kidney (nephritis), swollen ankles or high blood pressure, skin rashes, change in skin colour, severe blistering of the skin, being more sensitive to the sun than usual, high temperature (fever), and itching

•    Severe allergic reactions. The signs may include shock such as difficulty in breathing, cold clammy skin, pale skin colour and racing heart beat

•    Severe stomach or back pain. These could be signs of ‘pancreatitis’

•    Bruising more easily, getting more infections, feeling weak or tired more than usual. Frumil Tablets can affect the number of blood cells, causing serious blood problems

•    Increased thirst, headache, feeling dizzy or light-headed, fainting, confusion, muscle or joint pains or weakness, cramps or spasms, stomach upsets or uneven heartbeats. These could be signs of dehydration or changes in your normal body chemicals. Severe dehydration can also lead to blood clots or ‘gout’

•    You notice yellowing of your skin or eyes and your urine becomes darker in colour. These could be signs of a liver problem. In patients who already have liver problems, a more serious liver problem known as liver encephalopathy may occur. Symptoms include forgetfulness, fits, mood changes and coma.

•    Blistering or peeling of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever. This could be a condition called Stevens-Johnson syndrome. In a more severe form of the condition called Toxic Epidermal Necrolysis, layers of the skin may peel off to leave large areas of raw exposed skin all over the body.

Tell a doctor as soon as possible if you have any of the following side effects:

•    Problems hearing or ringing in the ears (tinnitus). This especially affects people who already have problems with their kidneys

•    Deafness

•    Tingling or feeling numb on the skin

•    Small changes in your mood such as feeling agitated or anxious.

•    Headaches, feeling dizzy or light-headed when standing up quickly. Also loss of concentration, slower reactions, feeling sleepy or weak, problems with your sight, dry mouth. This could be due to low blood pressure

Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days, or if you notice any side effects not listed in this leaflet

•    Feeling sick (nausea) or a general feeling of being unwell, diarrhoea and being sick (vomiting) and constipation

•    People with bladder and prostate problems may notice pain when passing water. This is due to an increase in the amount of water passed

•    If you have diabetes you may be less able to control the levels of glucose in your blood

•    Passing more water (urine) than you usually do. This normally happens 1 or 2 hours after taking this medicine.

Blood tests

Co-amilofruse can change the levels of liver enzymes or body fats known as cholesterol and triglycerides shown up on blood tests.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.qov.uk/vellowcard

By reporting side effects you can help provide more information on the safety of this medicine.

Procured from within the EU and repackaged by the Product Licence holder: B&S Healthcare, Unit 4, Bradfield Road, Ruislip, Middlesex,

HA4 0NU, UK.

This leaflet does not contain all the information about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist.

Co-Amilofruse 5mg/40mg Tablets fpoM-PL No: 18799/2403    -

Leaflet date: 20.05.2015

5. How to store Co-amilofruse


Keep out of the sight and reach of children Do not take Co-amilofruse after the expiry date which is stated on the carton and blister label after ‘Exp’. The expiry date refers to the last day of that month.

Do not store above 25°C.

Keep the blister strip in the outer carton in order to protect from light and moisture.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.


6. Further Information


What Co-amilofruse contains

The active substance is furosemide and amiloride hydrochloride.

Each tablet contains 40mg furosemide and 5mg amiloride hydrochloride.

The other ingredients are lactose monohydrate, maize starch, microcrystalline cellulose, sodium starch glycolate, sunset yellow (E110), talc, colloidal anhydrous silica and magnesium stearate.

What Co-amilofruse looks like and contents of the pack

Co-amilofruse is orange, evenly mottled circular tablet with bevel edges and ‘FRUMIL’ embossed on one side, with a breakline on the other. Co-amilofruse is available in calendar blister packs containing 28 tablets.


Co-amilofruse 5mg/40mg Tablets

(furosemide / amiloride hydrochloride)

Read all of this leaflet carefully before you start

taking this medicine

•    Keep this leaflet. You may need to read it again

•    If you have any further questions, ask your doctor or pharmacist

•    This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours

•    If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist

In this leaflet:

1.    What Co-amilofruse is and what it is used for

2.    Before you take Co-amilofruse

3.    Howto take Co-amilofruse

4.    Possible side effects

5.    Howto store Co-amilofruse

6.    Further information

1. What Co-amilofruse is and what it is used for

What Co-amilofruse is

The name of your medicine is Co-amilofruse 5mg/40mg Tablets (called Co-amilofruse throughout this leaflet). Co-amilofruse contains two different medicines called: furosemide and amiloride hydrochloride. Both belong to a group of medicines called diuretics (water tablets).

What Co-amilofruse is used for

Co-amilofruse can be used to stop the build up of extra water in your body. This extra water can cause swollen ankles, shortness of breath and feeling more tired than usual.

How Co-amilofruse works

Co-amilofruse works by helping you to pass more water (urine) than you usually do. If the extra water in your body is not removed, it can put extra strain on the heart, blood vessels, lungs, kidneys or liver.

x You are allergic to sulphonamides such as sulfadiazine or co-trimoxazole x You have severe problems with your kidneys x You have severe liver problems x Your doctor has told you that you have a low blood volume or are dehydrated x You are not passing any water (urine) x You have too much or too little potassium or sodium in your blood (shown in blood tests) x You have an illness called ‘Addison’s Disease’.

This can make you feel tired and weak, x You are breast-feeding (see “Pregnancy and breast-feeding” section below) x You are taking other medicines which change the amount of potassium in your blood (see “Taking other medicines” section below) x If the person taking the medicine is under 18 years. Co-amilofruse is not suitable for children Do not take Co-amilofruse if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Co-amilofruse.

Take special care with Co-amilofruse

Check with your doctor or pharmacist before

taking your medicine if:

▲    You have difficulty in passing water (urine)

▲    You are 65 years of age or older

▲    You have liver or kidney problems

▲    You are an elderly patient with dementia and are also taking risperidone

▲    You have diabetes

▲    You have low blood pressure or feel dizzy when you stand up

▲    You have prostate problems

▲    You have gout

▲    You feel dizzy or dehydrated. This can happen if you have lost a lot of water through being sick, having diarrhoea or passing water very often. It can also happen if you are having trouble drinking or eating

▲    You are going to have a glucose test

▲    You are taking any other water tablets

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Co-amilofruse.

2. Before you take Co-amilofruse

Do not take this medicine and tell your doctor if:

You are allergic (hypersensitive) to furosemide, amiloride hydrochloride or any of the other ingredients of Co-amilofruse (listed in Section 6)

Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue

Taking other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you buy without a prescription, including herbal medicines. This is because Co-amilofruse can affect the way some other medicines work.

Also, some medicines can affect the way Co-amilofruse works.


Do not take this medicine, and tell your doctor,

if you are taking:

•    Medicines which change the amount of potassium in your blood. These include potassium supplements such as potassium chloride or certain water tablets (diuretics) such as triamterene

The following medicines can affect the way

Co-amilofruse works and increase the chance

of you getting side effects:

•    Medicines such as ramipril, enalapril, perindopril (called ‘ACE inhibitors’) or losartan, candesartan, irbesartan (called ‘angiotensin II receptor antagonists’). Your doctor may need to change the dose of your tablets or ask you to stop taking them

•    Medicines for high blood pressure or heart problems. Your doctor may need to change the dose of your medicine

•    Medicines used as a general anaesthetic for relaxing your muscles during surgery

•    Medicines for diabetes. These may not work as well when you are taking Co-amilofruse.

•    Theophylline - used for wheezing or difficulty in breathing

•    Phenytoin - used for epilepsy. This can lower the effect of Co-amilofruse

The following medicines can increase the

chance of side effects when taken with

Co-amilofruse:

•    Lithium - used for mental illnesses. To help stop side effects your doctor may need to change the dose of your lithium and check the amount of lithium in your blood.

•    Cisplatin - used for some cancers

•    Digoxin - used for heart problems. Your doctor may need to change the dose of your medicine.

•    Non-steroidal anti-inflammatory drugs (NSAIDS) - used for pain and inflammation such as aspirin, ibuprofen, ketoprofen or indometacin

•    Carbamazepine - used for epilepsy

•    Aminoglutethimide - used for breast cancer

•    Ciclosporin - used to stop the rejection of organs after a transplant

•    Methotrexate - used for cancers of the skin, joint or bowel diseases

•    Carbenoxolone - used for ulcers of the foodpipe (gullet)

•    Reboxetine - used for depression

•    Amphotericin - used for fungal infections if used fora long time

•    Corticosteroids - used for inflammation such as prednisolone

•    Liquorice - often used in cough medicines if taken in large amounts

•    Probenecid (used with another HIV medicine)

•    Medicines for infection such as gentamicin, amikacin, neomycin, netilmicin, tobramycin, vancomycin or high doses of cephalosporins

•    Medicines used as injections before X-ray examinations

•    Medicines used for constipation (laxatives) if used for a long time such as bisacodyl or senna

•    Medicines for asthma when given in high doses such as salbutamol, terbutaline sulphate, salmeterol, formoterol orbambuterol

•    Other water tablets (diuretics) such as bendroflumethiazide. Your doctor may need to change the dose of your medicine

Pregnancy and breast-feeding

Do not take Co-amilofruse if you are pregnant. Talk to your doctor before taking this medicine if you are pregnant, might become pregnant, or think you might be pregnant.

Do not breast-feed if you are taking Co-amilofruse. This is because small amounts may pass into the mothers milk. Talk to your doctor before taking this medicine if you are breast-feeding or planning to breast-feed.

Ask your doctor or pharmacist for advice before taking any medicine if you are pregnant or breastfeeding.

Driving and using machines

You may feel dizzy or unwell after taking Co-amilofruse. If this happens, do not drive or use any tools or machines.

Important information about some of the ingredients of Co-amilofruse

This medicine contains:

•    A colour called ‘sunset yellow1 (E110). This may cause allergic reactions.

•    Lactose. If you have been told by your doctor that you cannot tolerate some sugars, talk to your doctor before taking this medicine

3. How to take Co-amilofruse

Always take Co-amilofruse exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

Taking this medicine

•    Take this medicine by mouth

•    Swallow the tablets whole with a drink of water

•    If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor

How much Co-amilofruse to take

The usual dose is one or two tablets first thing in the morning. Your doctor will tell you how many tablets to take.

If you are taking sucralfate (a medicine for stomach ulcers)

Do not take sucralfate at the same time as Co-amilofruse. Take your dose at least 2 hours before or after Co-amilofruse. This is because it can affect the way your medicine works.

If you take more Co-amilofruse than you should

If you think you may have taken more Co-amilofruse than you should, or if a child has swallowed any of your tablets, tell your doctor or got to your nearest hospital casualty department straight away. Remember to take with you any medicine that is left so the doctor knows what you have taken.

The following effects may happen: dry mouth, feeling thirsty, muscle pain or cramps, feeling sick or being sick (vomiting), weak or uneven heartbeat, feeling dizzy, weak or sleepy.

If you forget to take Co-amilofruse

If you forget a dose, take it as soon as you remember it. Then continue the following morning as normal. Do not take a double dose to make up for a forgotten dose.

If you stop taking Co-amilofruse

Keep taking Co-amilofruse until your doctor tells you to stop taking it.

Blood tests

Your doctor may carry out blood tests to check that the levels of some salts in the blood are at the correct levels.

rn

If you have any further questions onthe use of this product, ask your doctoror pharmacist.

4. Possible side effects

Like all medicines, Co-amilofruse can cause side effects, although not everybody gets them.

Tell a doctor straight away if you notice any of the following serious side effects - you may need urgent medical treatment

•    If you have an allergic reaction. The signs may include inflammation of the kidney (nephritis), swollen ankles or high blood pressure, skin rashes, change in skin colour, severe blistering of the skin, being more sensitive to the sun than usual, high temperature (fever), and itching

•    Severe allergic reactions. The signs may include shock such as difficulty in breathing, cold clammy skin, pale skin colour and racing heart beat

•    Severe stomach or back pain. These could be signs of ‘pancreatitis’

•    Bruising more easily, getting more infections, feeling weak or tired more than usual. Co-amilofruse can affect the number of blood cells, causing serious blood problems

•    Increased thirst, headache, feeling dizzy or light-headed, fainting, confusion, muscle or joint pains or weakness, cramps or spasms, stomach upsets or uneven heartbeats. These could be signs of dehydration or changes in your normal body chemicals. Severe dehydration can also lead to blood clots or ‘gout’

•    You notice yellowing of your skin or eyes and your urine becomes darker in colour. These could be signs of a liver problem. In patients who already have liver problems, a more serious liver problem known as liver encephalopathy may occur. Symptoms include forgetfulness, fits, mood changes and coma.

•    Blistering or peeling of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever. This could be a condition called Stevens-Johnson syndrome. In a more severe form of the condition called Toxic Epidermal Necrolysis, layers of the skin may peel off to leave large areas of raw exposed skin all over the body.

Tell a doctor as soon as possible if you have any of the following side effects:

•    Problems hearing or ringing in the ears (tinnitus). This especially affects people who already have problems with their kidneys

•    Deafness

•    Tingling or feeling numb on the skin

•    Small changes in your mood such as feeling agitated or anxious.

•    Headaches, feeling dizzy or light-headed when standing up quickly. Also loss of concentration, slower reactions, feeling sleepy or weak, problems with your sight, dry mouth. This could be due to low blood pressure

Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days, or if you notice any side effects not listed in this leaflet

•    Feeling sick (nausea) or a general feeling of being unwell, diarrhoea and being sick (vomiting) and constipation

•    People with bladder and prostate problems may notice pain when passing water. This is due to an increase in the amount of water passed

•    If you have diabetes you may be less able to control the levels of glucose in your blood

•    Passing more water (urine) than you usually do. This normally happens 1 or 2 hours after taking this medicine.