Package leaflet: Information for the patient Co-Fluampicil 250/250 mg capsules, hard

(ampicillin trihydrate and flucloxacillin sodium)

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

•    Keep this leaflet. You may need to read it again.

•    If you have any further questions, ask your doctor or pharmacist. • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. • If you get any side effects talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

What is in this leaflet:

1.    What Co-Fluampicil is and what it is used for.

2.    What you need to know before you take Co-Fluampicil.

3.    How to take Co-Fluampicil.

4.    Possible side effects.

5.    How to store Co-Fluampicil.

6.    Contents of the pack and other information.

1. What Co-Fluampicil is and what it is used for Co-Fluampicil contains flucloxacillin and ampicillin, which belong to the group of antibiotics called 'Penicillins'. Antibiotics are used to kill the bacteria that cause infections.

Your doctor will have prescribed Co-Fluampicil for treating an infection. Co-Fluampicil can be used for treating a wide range of infections, for example

infections of the chest (bronchitis or pneumonia), sinuses (sinusitis), ears (otitis media), nose, throat, skin and soft tissues.

It can also be used to treat chest and wound infections following surgery or for the treatment of septicaemia (infections in the blood), treatment of infection following childbirth or termination of pregnancy. It can also be used to treat patients who are prone to infection (e.g. following a bone marrow transplant) or given before major surgery to prevent infection.

2. What you need to know before you take Co-Fluampicil

Do not take Co-Fluampicil if:

• you are allergic to ampicillin, flucloxacillin or any of the other ingredients of this medicine (listed in section 6)

•    you are allergic to penicillin or any other antibiotic

•    you have experienced liver problems when taking an antibiotic.

Warnings and precautions

Talk to your doctor before taking Co-Fluampicil if:

•    you suffer from kidney or liver disease including jaundice (the skin and whites of the eyes turn yellow)

•    you have a history of allergies

•    you have any conditions affecting your white blood cells (e.g. infectious mononucleosis or lymphoid leukaemia)

•    you are having a urine test (ampicillin can affect tests for glucose in urine).

Other medicines and Co-Fluampicil

Please tell your doctor or pharmacist if you are taking,

have recently taken or might take any other medicines,

including medicines obtained without a prescription,

especially any of the following:

•    allopurinol or probenecid (used to treat gout)

•    oral contraceptives ('the pill'); you should take additional contraceptive precautions as advised by your doctor

•    anti-coagulation therapy (such as warfarin); the tendency to bleed may increase

•    methotrexate (used to treat some types of cancer, severe psoriasis or severe arthritis

•    other antibiotics.

Pregnancy and breast-feeding

Co-Fluampicil should only be given to pregnant or breast-feeding mothers if the benefits to the mother outweigh the risks to the baby. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard 3y reporting side effects you can help provide more nformation on the safety of this medicine.

5. How to store Co-Fluampicil

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date, which

is stated on the carton or label after 'EXP'. The expiry date refers to the last day of that month. Store below 25°C.

Store in the original package and keep the container tightly closed in order to protect from moisture.

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.

6. Contents of the pack and other information

What Co-Fluampicil contains

The active substances are ampicillin trihydrate (equivalent to 250 mg of ampicillin) and flucloxacillin sodium (equivalent to 250 mg of flucloxacillin).

This combination of active substances is also known as Co-Fluampicil.

The other ingredients are magnesium stearate, gelatin, quinoline yellow (E104), patent blue (E131), titanium dioxide (E171) and iron oxides (E172).