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Fruit Flavoured Antacid Tablets

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SUMMARY OF PRODUCT CHARACTERISTICS

1    NAME OF THE MEDICINAL PRODUCT

Fruit Flavoured Antacid Tablets - Lemon

2. QUALITATIVE AND QUANTITATIVE COMPOSITION

INGREDIENT    QTY UNIT DOSE

Calcium Carbonate    500    Mg per tablet

3.    PHARMACEUTICAL FORM

Tablet

4    CLINICAL PARTICULARS

4.1.    Therapeutic indications

For relief from indigestion, dyspepsia, heartburn, acidity and flatulence.

4.2.    Posology and method of administration

Take one or two tablets, as required, up to a maximum of 16 tablets a day. Suck slowly or chew as preferred.

There is no distinction between adults and the elderly on the pack.

Not recommended for children under 12 years.

4.3    Contraindications

Hypersensitivity to any of the ingredients.

Patients with hypercalcaemia, hyperparathyroidism, hypercalciuria, nephrolithiasis and Zollinger-Ellison syndrome.

Patients on a low phosphate diet.

Patients on cardiac glycosides.

Patients with impaired renal function.

Patients with rare glucose-galactose malabsorption should not take this medicine.

4.4 Special Warnings and Precautions for Use

If symptoms persist consult your doctor.

Keep all medicines out of the sight and reach of children.

The leaflet shall say:

Each lemon tablet contains 524 mg of glucose (dextrose) per tablet. This should be taken into account in patients with diabetes mellitus.

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

4.5. Interactions with other medicaments and other forms of interaction

The following are noted but are unlikely to apply when the product is used for short-term symptomatic relief, as directed:

Tetracyclines    -    Calcium    Carbonate and other antacids may interfere

with the absorption of concomitantly administered tetracycline preparations.

Bisphosphonates    -    Calcium    Carbonate and other antacids reduce

absorption of bisphosphonates.

Thiazide Diuretics    -    Calcium    Carbonate may increase the risk of

hypercalcaemia.

4.6. Pregnancy and lactation

the use of Calcium Carbonate in


There are no adequate safety data from pregnant women.

use for many years without ill


Calcium Carbonate has been in wide consequence.

Caution should be exercised when treating pregnant women with Calcium Carbonate, particularly during the first trimester.

No problems are anticipated when using this product during lactation.

4.7. Effects on ability to drive and use machines

None known.

4.8. Undesirable effects

Calcium Carbonate can cause constipation and flatulence.

Hypercalcaemia can occur as can alkalosis following the regular use of Calcium Carbonate. The milk-alkali syndrome has occasionally occurred in patients taking large doses. ‘Acid Rebound’ has been reported on cessation of Calcium Carbonate.

4.9. Overdose

Hypercalcaemia - Remove source of calcium. Rehydration may be necessary (if necessary with intravenous 0.9% sodium chloride) and a loop diuretic may be given to increase urinary calcium excretion.

5 PHARMACOLOGICAL PROPERTIES

5.1 Pharmacodynamic properties

Antacid.

Mechanism of Action/Effect

Calcium Carbonate reacts chemically to neutralise or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. It also reduces acid concentration within the lumen of the oesophagus, thus causing an increase in intra-oesophageal pH and a decrease in pepsin activity, which aids in the control of gastro-oesophageal reflux.

ATC code: A02AC01.

5.2. Pharmacokinetic properties

Not applicable.

5.3. Preclinical safety data

Not applicable.

6 PHARMACEUTICAL PARTICULARS

6.1. List of Excipients

Microcrystalline Cellulose Maize Starch Dextrose Monohydrate Sodium Saccharin Magnesium Stearate Quinoline Yellow Lake E104 Lemon Flavour 610364E

6.2. Incompatibilities

None known.

6.3. Shelf Life

3 years.

6.4. Special Precautions for Storage

None.

6.5. Nature and Contents of Container

250 micron clear white UPVC/20 micron hard temper, heat seal coated aluminium foil.

24, 48, 72, 96 tablets/carton.

HDPE drum with polyethylene tamper evident caps.

72, 75, 96, 100 tablets/drum.

Roll wrap of 20 tablets in 0.2 gsm Lacquer/0.009 mm soft aluminium foil/7 gsm wax/32 gsm paper.

40, 60, 80, 100, 120 packs will be 2, 3, 4, 5, 6 rolls in a carton.

6.6. Instructions for use, handling and disposal

None.

7    MARKETING AUTHORISATION HOLDER

Wrafton Laboratories Limited

Wrafton

Braunton

North Devon

EX33 2DL

8. MARKETING AUTHORISATION NUMBER

PL 12063/0017

9. DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION

First Authorisation: 28th July 1993

10 DATE OF REVISION OF THE TEXT

19/12/2012