- Ranitidine Hydrochloride 75 mg

"Please read right through this leaflet before you start using this medicine. This .medicine is available without prescription, but you still need to use Zantac 75 carefully to get the best results from it.

Keep this leaflet, you may need to read it again.

If you have any questions, or if there is anything you do not understand, ask your pharmacist.

In this leaflet:

_1. What Zantac 75 does 2. Check before you take Zantac 75 -3. How to take Zantac 75 4. Possible side effects "5. How to store Zantac 75 _6. Further information

1.    What Zantac 75 does

-Zantac 75 is used to treat and prevent indigestion and heartburn for up to 12 hours.

The stomach produces acid which helps to digest food. Sometimes your stomach "produces too much acid which can cause indigestion and heartburn.

The active ingredient is ranitidine hydrochloride which is a medicine called an 'H2-blocker'. It works by preventing your stomach from producing too much acid.

2.    Check before taking Zantac 75

Do not take Zantac 75:

if you have ever had an allergic reaction to ranitidine or to any of the other ingredients (listed in Section 6) if you are under 16 years.

Ask your doctor before you take this medicine:

if you have kidney or liver problems

if you have porphyria (too much of the pigment called porphyrin which may discolour the urine)

if you have unintended weight loss associated with acid indigestion if you are middle-aged or older with new or recently changed indigestion symptoms

if you have persistent stomach pain if you are under regular medical supervision if you are elderly if you have breathing problems if you have a weak immune system if you suffer from diabetes.

If you are taking other medicines

Talk to your doctor or pharmacist before taking Zantac 75 if you are taking any other medicines, including those obtained without a prescription; particularly medicines to prevent blood clotting, such as warfarin, medicines for insomnia (e.g. triazolam, midazolam), medicines for lowering blood glucose (e.g. glipizide), medicines for fungal infections (e.g. ketoconazole, itraconazole, posaconazole), medicines for treating HIV infection (e.g. atazanavir, delavirdine), medicines for lung'

I Lcancer (e.g. gefitnib) and non-steroidal anti-inflammatory painkillers (e.g. aspirin or —, I—, ibuprofen). This advice is even more important if you are elderly.

Pregnancy and breast feeding

Talk to your doctor before taking Zantac 75 if you are pregnant, trying to become pregnant or are breast feeding.

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Adults and children aged 16 years and over: Swallow 1 tablet, with a drink of water, as soon as you have symptoms.

If symptoms persist for more than one hour or return, take another tablet.

To prevent your symptoms, you can take 1 tablet half an hour to an hour before eating or drinking.

•    Do not take more than 4 tablets in 24 hours.

•    Do not take for longer than 2 weeks at a time.

•    Do not take more than the recommended dose.

If you take too many tablets

Contact your doctor or casualty department.

_4. Possible side effects

Like all medicines, Zantac 75 can have side effects, but they are rare.

Stop taking the medicine and tell your doctor immediately if you experience:

Allergic reactions. These are very rare but may include developing an itchy rash, swelling of the eyelids, face or lips (with or without a lumpy skin rash elsewhere on the body), unexplained fever, difficulty breathing, dizziness (especially on standing up) and chest pain or tightness.

Unexplained bruising or bleeding, sore throat, mouth ulcers, fever, extreme paleness, weakness or exhaustion. These can be signs of blood disorders such as anaemia, low white blood cells, low platelet count, suppressed bone marrow or reduction in agranulocytes (a type of white blood cell).

The following side effects may occur. Tell your doctor if you get them.

Confusion, depression, drowsiness or hallucinations.

Headache, dizziness or sudden, jerky movements.

Changes in heart rhythm.

Inflammation of your blood vessels.

Sudden inflammation of your pancreas (you may get severe stomach pain) or diarrhoea.

Stomach pain, constipation, feeling sick (nausea).

Inflammation of your liver which may cause one or more of the following: feeling or being sick, fever, itching, yellowing of the skin and eyes, dark coloured urine. This can cause changes to your liver function tests.

Hair loss, blurred vision.

Aches and pains in your muscles and joints.

Sudden inflammation of your kidneys.

Increase of serum creatine in the blood (kidney function test).

Blood in your urine or changes in the normal amount of urine.

Impotence.

Swollen, tender or leaking breasts.

Reporting of side effects:

'If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard. By reporting side -effects, you can help provide more information on the safety of this medicine.

5.    How to store Zantac 75

Keep out of the reach and sight of children.

"Do not use this medicine after the 'EXP' date shown on the pack. Store below 25°C. .Tablets should not be removed from blisters until immediatiately prior to use.

6.    Further information

Active ingredients Each tablet contains Ranitidine Hydrochloride 84 mg (equivalent "to Ranitidine 75 mg). Other ingredients Microcrystalline cellulose, magnesium stearate, hypromellose (E 464), titanium dioxide (E 171), red iron oxide (E 172) and triacetin.

Packs of Zantac 75 contain 24 or 48 tablets.

The marketing authorisation holder is Omega Pharma Ltd., 32 Vauxhall Bridge Road, -London, SW1V 2SA, United Kingdom and all enquiries should be sent this address.

-Manufactured by: Glaxo Wellcome SA, Aranda de Duero, Burgos, Spain or Omega Pharma International, Venecoweg 26, B-9810 Nazareth, Belgium.

Zantac is a registered trademark of the GlaxoSmithKline group of companies and is ■used under licence.

'This leaflet was revised in February 2016

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