Zido-Co Tablets 5/50
PACKAGE LEAFLET: INFORMATION FORTHE USER
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Read all ofthis leaflet carefully before you start taking this medicine because it contains important information for you.
|* Keep this leaflet. You may need to read it again.
[• If you have any further questions, ask your doctor or pharmacist or nurse.
[• This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
|* If you get any side effects, talk to your doctor, pharmacist or nurse. This includes possible side effects not listed in this leaflet. See section 4.
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What is in this leaflet:
|1. What Zido-Co Tablets are and what they are used for
|2. What you need to know before you take Zido-Co Tablets
|3. How to take Zido-Co Tablets
4. Possible side effects
|5. How to store Zido-Co Tablets
6. Contents of the pack and other information
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fcido-Co Tablets contain the active ingredients amiloride hydrochloride and hydrochlorothiazide, both ofthese actives belong to a group of ^medicines called diuretics (water tablets).
Zido-Co Tablets are used in the treatment of high blood pressure and to treat heart failure. Zido-Co Tablets are also used to treat other conditions where fluid retention occurs, including a liver jdisease called hepatic cirrhosis.
Zido-Co Tablets can also be used in patients where loss of potassium in the blood is anticipated or
^Do not take Zido-Co Tablets if:
• you are allergic (hypersensitive) to amiloride
I hydrochloride, hydrochlorothiazide or any of the I other ingredients in these tablets (listed in I section 6)
• you are allergic to medicines called
' sulphonomides (for the treatment of infections)
• you have been told you have a high level of
1 potassium, calcium, urea or creatinine in your I blood
L you are taking other potassium containing | products including supplements and potassium rich foods
» you are currently taking other medicines such as spironolactone and triamterene (see section | Other medicines and Zido-Co Tablets)
• you are not passing water (urine) to you have severe kidney disease
• you have severe liver failure |* you have Addison's disease
• you are taking lithium
[• you have diabetic neuropathy (diabetic nerve damage causing pain, weakness or | numbness).
^ido-Co Tablets should not be used in children under18years ofage
arnings and precautions [Talk to your doctor, pharmacist or nurse before taking this medicine ifyou have:
|* liver cirrhosis with swelling of the abdomen
(ascites) and abnormally high levels of alkalinity in the body (metabolic alkalosis)
• had high levels ofacid in the body (metabolic or respiratory acidosis) caused by heart disease or poorly controlled diabetes
|* water retention causing swelling (resistant oedema)
|* severe liver disease
• impaired kidney function
I* had surgery affecting nerves
• become pregnant or are breast-feeding
• had systemic lupus erythematosus (SLE).
Other medicines and Zido-Co Tablets
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
This is particularly important if you are taking any of the following:
• Diuretics such as spironolactone or triamterene
• Medicines for your heart e.g. ACE inhibitors, beta-blockers e.g. Sotalol, Alpha-blockers e.g. prazosin, calcium channel blockers, angiotensin II antagonists, digoxin, amiodarone, disopyramide, flecainide, quinidine or sympathomimetics
• Ciclosporin - used to treat psoriasis and used after organ transplants
• Non-steroidal anti-inflammatory drugs (NSAIDs) e.g. indomethacin, used for arthritis and pain relief
• Barbiturates for sleeping problems
• Antidepressants - tricyclics or reboxetine
• Narcotics e.g. dihydrocodeine
• Medicines for diabetes e.g. insulin, chlorpropamide
• Medicines containing Vitamin D (sometimes called calciferol or ergocalciferol for the treatment of soft bones) or calcium salts
• Corticosteroids therapy e.g. prednisolone Corticotrophin (ACTH), trilostane
• Medicines or supplements containing potassium
• Alprostadil and moxisylate used for erectile dysfunction
• Amphotericin and fluconazole to treat fungal infections
• Acetazolamine used to treat glaucoma
• Carbenoxolone to treat stomach ulcers
• Terfenadine to treat allergic conditions
• Toremifene and aminogluthethimide to treat breast cancer
• Halofantrine to treat malaria
• Carbamazepine and primozide used to treat epilepsy
• Adrenaline
• Baclofen, tubocurarine and tizanidine muscle relaxants
• Cisplatin, to treat cancer
• Colestyramine or colestipol used to treat high cholesterol
• Medicines containing oestrogen combined pill or HRT treatments
• Lithium used to treat some mental illnesses.
You should take care if drinking alcohol while taking these tablets as it may cause you to feel dizzy or faint when standing up.
If you are already taking a medicine to treat high blood pressure, your doctor may have reduced the dose of that medicine before starting you on Zido-Co Tablets. If your doctor decides that you should take Zido-Co Tablets and an ACE-inhibitor at the same time he will want to monitor your condition regularly.
If you are going to have surgery you should let the doctor or nurse know you are taking Zido-Co Tablets as they can interfere with medicines used.
Ifyou need to have a blood or urine test while taking this medicine you should let the doctor or nurse know you are taking Zido-Co Tablets.
Pregnancy
You must tell your doctor if you are pregnant or if you think that you are. Usually, your doctor will advise you to take another medicine instead of Zido-Co Tablets, as this product is not recommended during pregnancy. This is because this medicine crosses the placenta and its use after the third month of pregnancy may cause potentially harmful foetal and neonatal effects.
Breast-feeding
Tell your doctor if you are breast-feeding or about to start breastfeeding. Zido-Co Tablets are not recommended for mothers who are breast-feeding.
driving and using machines
These tablets can cause you to have headaches, visual disturbances, confusion, dizziness and vertigo. If you suffer from any of these while taking these tablets you should not drive or operate [machinery until you feel better.
ido-Co Tablets contain lactose and sunset ellow (E110)
ilfyou have been told by your doctor that you have an intolerance to some sugars, you should talk to ^our doctor before taking these tablets.
These tablets contain E110 (sunset yellow) which may cause allergic reactions.
3. HOW TO TAKE ZIDO-CO TABLETS
Always take Zido-Co Tablets exactly as your poctor has told you. If you are not sure you should check with your doctor or pharmacist before [taking.
|Swallow the tablets with a drink ofwater.
[Treatment of high blood pressure:
Half a tablet daily.
Treatment of heart failure:
|Half a tablet daily.
[Treatment of liver cirrhosis:
One tablet daily.
Your doctor may change the dose depending upon ^our response to these tablets. Exactly how much you should take will be on the dispensing label of fhe packet.
Ilfyou take too many tablets
If you (or someone else) swallow a lot of the gablets all together, or if you think a child has swallowed any of the tablets, contact your nearest hospital casualty department or your doctor immediately. An overdose is likely to cause dehydration and an imbalance of blood mineral salt in the body (causing abnormal heart rhythm, muscle twitching, muscle weakness, tiredness and confusion). Please take this leaflet, any remaining tablets and the container with you to the hospital or they know which tablets were
Ilf you forget to take a dose
,lfyou forget to take your tablet, take the missed dose as soon as you remember unless it is nearly time to take the next one. Never take two doses together. Then continue to take your tablets at the
Eorrect times. If you have trouble remembering rhen to take your tablets talk to your doctor.
Ilfyou stop taking these tablets
You should finish all the tablets your doctor has prescribed. Even ifyou feel betteryou should not stop taking these tablets before talking to your doctor.
doctor so that consumed.
4. POSSIBLE SIDE EFFECTS
'Like all medicines, this medicine can cause side effects, although not everybody gets them.
Tell your doctor or pharmacist ifyou notice any iof the following side effects, if they get worse or ifyou notice anything not listed.
• Altered balance offluid or chemicals in the body (e.g. sodium, potassium, chlorine and magnesium) causing a dry mouth, weakness, tiredness or drowsiness, restlessness, fits, muscle pain, fatigue or cramps, low blood pressure, difficulty passing water, fast heart rate, feeling and being sick.
]• Blood: altered numbers and types ofblood cells causing increased bruising, nosebleeds, sore throats, infections, excessive tiredness, breathlessness on exertion or abnormal paleness ofthe skin (you may need a blood test).
|* Metabolism: dehydration, gout, changes in levels of body chemicals (increased blood potassium, glucose or uric acid or decreased blood sodium), glucose in the urine.
|* Nervous system: depression, difficulty
sleeping or sleepiness, confusion, nervousness and restlessness, dizziness, pins and needles or tingling, near unconsciousness including reduced mental activity and reduced response to stimulation (stupor), feeling of dizziness or spinning (vertigo), tremors and brain disease (characterised by poor concentration, confusion and delirium).
Heart: chest pain (angina), irregular |
(arrhythmia), fast (tachycardia) or
pounding (palpitation) heart beat,
dizziness on standing due to low m
blood pressure and inflammation of I
blood vessels (necrotising angiitis). m
Breathing: cough, difficulty breathing,]
fluid in the lungs and lung
inflammation (pneumonitis). | m
Stomach and intestines: feeling of
stomach fullness, cramps, stomach L _
irritation or pain, activation ofstomach ulcers, bleeding in the stomach or intestines, indigestion, wind, loss or other appetite changes, constipation or diarrhoea, hiccups, feeling or being sick.
Liverand pancreas: inflammation ofthe pancreas (pancreatitis) and changes in liver function, jaundice (yellow skin or eyes).
Skin: blood spots, bruising and discolouring to the skin (purpura), loss of hair, itching, skin rash, pale or red irregular raised patches with severe itching (hives), flushing, sensitivity of the skin to sunlight or artificial light (e.g. sunbeds), sweating and swelling ofthe salivary glands.
Muscles and joints: joint pain, aching legs and muscle cramps.
Urinary and genital: pain on passing water, getting up in the night to pass water, frequent or copious water production, inability to control bladder movements, bladder pain, impaired kidney function, kidney failure or inflammation, decreased desire for sex and inability to maintain an erection. You should consult your doctor if these are troublesome or continue. Senses: bad taste, stuffy nose, ringing in the ears, increased pressure in the eyes, visual disturbances and yellow vision.
Other: dry mouth, thirst, allergic (anaphylactic) reactions (rash, swelling, difficulty breathing), back, chest, neck and shoulder pain, pain in the hands and feet, tiredness, a feeling of general discomfort and illness, weakness, fever, headache and fainting.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard By reporting side effects you can help provide more information on the safety of this medicine.
5. HOW TO STORE ZIDO-CO TABLETS
Keep out of the sight and reach of children.
Do not store above 25°C. Store in the original package.
Do not use Zido-Co Tablets after the expiry date stated on the pack. The expiry date refers to the last day of that month.
Medicines should not be disposed ofvia wastewater of household waste. Ask your pharmacist how to dispose of unwanted medicines no longer required. These measures will help protect the environment.
6. CONTENTS OF THE PACK AND OTHER INFORMATION
What Zido-Co Tablets contain I
Zido-Co Tablets contain 5mg of amiloride hydrochloride and 50mg of hydrochlorothiazide. I
The other ingredients are lactose, microcrystalline , cellulose, maize starch, magnesium stearate, I
purified talc, sodium starch glycollate and sunset ,
WhatZido-Co Tablets look like and contents of I the pack i
Zido-Co Tablets are flat, pale peach bevelled 1
edged tablets bisected on one side, embossed i
Zido-Co Tablets are available in packs of28, 50, 100and 500tablets. |
MARKETING AUTHORISATIONHOLDER: |
Ennogen Pharma Limited
Unit G4, Riverside Industrial Estate,
Riverside Way, Dartford, DA1 5BS, UK.
MANUFACTURER:
Sussex Pharmaceuticals Limited Charleswood Road, East Grinstead, Sussex RH19 2111, UNITED KINGDOM I
-This-leaflet was fast revised in-March 2-046.— J