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Rapitil 2% W/V Eye Drops

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Document: leaflet MAH BRAND_PLPI 15184-1277 change

Ref: 1277/080616/1/F

Rapitil ®2% w/v Eye Drops

(nedocromil sodium)

Patient Information Leaflet


Read all of this leaflet carefully before you start using this medicine

•    Keep this leaflet. You may need to read it again.

•    If you have any further questions, ask your doctor or pharmacist.

•    This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.

•    If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. See section 4.

Your medicine is called Rapitil 2% w/v Eye Drops, but will be referred to as Rapitil Eye Drops through out this leaflet.

In this leaflet:

[2 What Rapitil Eye Drops are and what they are used for

[2 Before you use Rapitil Eye Drops [2 How to use Rapitil Eye Drops [2 Possible side effects [2 How to store Rapitil Eye Drops 2 Further information

What Rapitil Eye Drops are and what they are used for

What Rapitil Eye Drops are

Rapitil 2% Eye Drops (called Rapitil Eye Drops in this leaflet) contain a medicine called nedocromil sodium. This belongs to a group of medicines called anti-allergics.

How Rapitil Eye Drops work

It works by stopping the release of the natural substances in your eyes that can lead to an allergic reaction.

What Rapitil Eye Drops can be used for

Stopping, treating and relieving the symptoms of ‘allergic conjunctivitis' (inflammation of parts of the eye). Rapitil Eye Drops can be used for three types of allergic conjunctivitis:

•    ‘Perennial allergic conjunctivitis' in adults only:

This type of allergy can happen at any time of the year and is often caused by animal fur or house dust mites. Signs include itchy, watery, red or inflamed eyes and puffy eyelids.

•    ‘Seasonal allergic conjunctivitis' in adults and children: This type of allergy, such as hay fever, can be caused by different pollens in different seasons of the year. Signs include itchy, watery, red or inflamed eyes and puffy eyelids.

•    ‘Vernal kerato conjunctivitis' in adults and children: This is a more severe type of allergy. Signs include bumps inside the upper eyelid, sensitivity to light and severe itching.

^2 Before you use Rapitil Eye Drops

Do not use this medicine and tell your doctor or pharmacist if:

•    You are allergic (hypersensitive) to nedocromil sodium, or any of the other ingredients of Rapitil Eye Drops (listed in Section 6 below) Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue or around the eyes

Do not use this medicine if the above applies to you. If you are not sure, talk to your doctor or pharmacist before using Rapitil Eye Drops.

Take special care with Rapitil Eye Drops if:

•    You wear soft contact lenses. You should not wear soft contact lenses while using these drops

If you are not sure if this applies to you, talk to your doctor or pharmacist before using Rapitil Eye Drops.

Pregnancy and breast-feeding

Talk to your doctor before using this medicine if you are pregnant, might become pregnant or think you may be pregnant.

If you are breast-feeding or planning to breast-feed, talk to your doctor or pharmacist before taking or using any medicine.

Driving and using machines

Your eyesight may be affected after using this medicine. If this happens, do not drive or use any tools or machines until you can see clearly.

Important information about some of the ingredients of Rapitil Eye Drops

Rapitil Eye Drops contain benzalkonium chloride. This may cause your eyes to become irritated. It may also change the colour of your contact lenses.

[3) How to use Rapitil Eye Drops

Always use Rapitil Eye Drops exactly as your doctor

or pharmacist has told you. You should check with

your doctor or pharmacist if you are not sure.

Using this medicine

•    If you wear hard or gas-permeable contact lenses, you should take them out while you use the eye drops. You should wait 15 minutes before you put the contact lenses back in

•    If you need to use more than one type of eye medicine, the medicines must be used at least 5 minutes apart. Eye ointments should be used last.

•    If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor or pharmacist

How to use this medicine

•    Wash your hands

•    Remove the cap from the bottle

•    Tilt your head back

•    Squeeze one or two drops inside the lower lid without touching your eye

•    Close your eye

•    Wipe away any excess liquid from the eyes with a clean tissue

•    Always put the cap back on the bottle as soon as you have used it

•    Repeat in the other eye as needed How much to use

Adults, Elderly and Children aged 6 years and over

Seasonal allergic conjunctivitis:

•    One drop into each eye twice each day

•    This can be increased to four times each day if needed

•    Do not use for more than 12 weeks Vernal kerato-conjunctivitis

•    One drop into each eye four times each day

Adults and the Elderly only Perennial allergic conjunctivitis:

•    One drop into each eye twice each day

•    This can be increased to four times each day if needed

•    Use the drops regularly Children under 6 years

This medicine is not recommended for children aged less than 6 years.

If you take more Rapitil Eye Drops than you should

If you use more Rapitil than you should, talk to your doctor or go to a hospital straight away. Remember to take any medicine that is left with you so the doctor knows what you have taken.

If you forget to use Rapitil Eye Drops

If you forget a dose, use your drops as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose. Do not use a double dose to make up for a forgotten dose.

If you stop using Rapitil Eye Drops

Keep using the eye drops for as long as your doctor or pharmacist advises you. If you stop using Rapitil Eye drops too early, your allergy symptoms may come back.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

^ Possible side effects

Like all medicines, Rapitil Eye Drops can cause side effects, although not everybody gets them.

Stop using Rapitil Eye Drops and see a doctor as soon as possible if:

•    The itching, redness or swelling gets worse. You may be allergic to these drops

Talk to your doctor or pharmacist if any of the side effects gets serious or lasts longer than a few days, or if you notice any side effects not listed in this leaflet:

Common (affects 1 to 10 people in a 100)

•    Stinging or burning in your eyes or blurring of eyesight. This should only last for a short time and occurs immediately after using the eye drops

•    Change in the way things taste Uncommon (affects 1 to 10 people in a 1,000)

•    Mild eye irritation

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard By reporting side effects you can help provide more information on the safety of this medicine.

Eye drops should be kept in the original carton and not stored above 25°C and out of direct sunlight.

KEEP OUT OF THE SIGHT AND REACH OF CHILDREN

Avoid contamination of the contents by replacing the cap securely after use.

You must not use the eye drops after the expiry date. This is given in two places on the end flap of the carton and on the bottle label. In both places it is given as EXP followed by the month and year. The eye drops should not be used after the end of this month. Discard the eye drops four weeks after opening the first time.

Remember this medicine is for you. It can only be prescribed by a doctor. Never give your medicine to other people. It may harm them, even if their symptoms are the same as yours. This leaflet does not tell you everything about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist (chemist). He/she will have additional information about this medicine and will be able to advise you.

3 Further Information

What Rapitil Eye Drops contain

Contains nedocromil sodium 2% w/v.

Your medicine also contains the following inactive ingredients Benzalkonium chloride, sodium chloride, disodium edetate, and purified water.

The active ingredient belongs to a group of medicines known as anti-allergic / anti-inflammatory agents.

What Rapitil Eye Drops looks like and contents of the pack

This medicine is presented as a 5 ml sterile solution. Each ml of solution contains 20mg of nedocromil sodium, in a dropper bottle for administration to the eye.

Manufacturer and Licence Holder

The eye drops are manufactured by Sanofi Winthrop Industrie, Boulevard Industrial, Le Trait F-76580, France and procured from within the EU and repackaged by the Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE.

I POM PL 15184/1277

Leaflet revision date: 08/06/16

Rapitil is a registered trademark of Fisons Limited

Blind or partially sighted?

Is this leaflet hard to see or read? Phone Lexon (UK) Limited,

Tel: 01527 505414 for help.

Tilavist® 2% w/v Eye Drops

(nedocromil sodium)

Patient Information Leaflet


Read all of this leaflet carefully before you start using this medicine

•    Keep this leaflet. You may need to read it again.

•    If you have any further questions, ask your doctor or pharmacist.

•    This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.

•    If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. See section 4.

Your medicine is called Tilavist 2% Eye Drops, but will be referred to as Tilavist Eye Drops through out this leaflet.

In this leaflet:

What Tilavist Eye Drops are and what they are used for

[2 Before you use Tilavist Eye Drops [2 How to use Tilavist Eye Drops [2 Possible side effects [2 How to store Tilavist Eye Drops r2 Further information

M What Tilavist Eye Drops are and what they are used for

What Tilavist Eye Drops are

Tilavist 2% Eye Drops (called Tilavist Eye Drops in this leaflet) contain a medicine called nedocromil sodium. This belongs to a group of medicines called anti-allergics.

How Tilavist Eye Drops work

It works by stopping the release of the natural substances in your eyes that can lead to an allergic reaction.

What Tilavist Eye Drops can be used for

Stopping, treating and relieving the symptoms of ‘allergic conjunctivitis' (inflammation of parts of the eye). Tilavist Eye Drops can be used for three types of allergic conjunctivitis:

   ‘Perennial allergic conjunctivitis' in adults only: This type of allergy can happen at any time of the year and is often caused by animal fur or house dust mites. Signs include itchy, watery, red or inflamed eyes and puffy eyelids.

   ‘Seasonal allergic conjunctivitis' in adults and children: This type of allergy, such as hay fever, can be caused by different pollens in different seasons of the year. Signs include itchy, watery, red or inflamed eyes and puffy eyelids.

   Vernal kerato conjunctivitis' in adults and children: This is a more severe type of allergy. Signs include bumps inside the upper eyelid, sensitivity to light and severe itching.

^ Before you use Tilavist Eye Drops

Do not use this medicine and tell your doctor or pharmacist if:

•    You are allergic (hypersensitive) to nedocromil sodium, or any of the other ingredients of Tilavist Eye Drops (listed in Section 6 below) Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue or around the eyes

Do not use this medicine if the above applies to you. If you are not sure, talk to your doctor or pharmacist before using Tilavist Eye Drops.

Take special care with Tilavist Eye Drops if:

•    You wear soft contact lenses. You should not wear soft contact lenses while using these drops

If you are not sure if this applies to you, talk to your doctor or pharmacist before using Tilavist Eye Drops.

Pregnancy and breast-feeding

Talk to your doctor before using this medicine if you are pregnant, might become pregnant or think you may be pregnant.

If you are breast-feeding or planning to breast-feed, talk to your doctor or pharmacist before taking or using any medicine.

Driving and using machines

Your eyesight may be affected after using this medicine. If this happens, do not drive or use any tools or machines until you can see clearly.

Important information about some of the ingredients of Tilavist Eye Drops

Tilavist Eye Drops contain benzalkonium chloride. This may cause your eyes to become irritated. It may also change the colour of your contact lenses.

[2 How to use Tilavist Eye Drops

Always use Tilavist Eye Drops exactly as your

doctor or pharmacist has told you. You should check

with your doctor or pharmacist if you are not sure.

Using this medicine

•    If you wear hard or gas-permeable contact lenses, you should take them out while you use the eye drops. You should wait 15 minutes before you put the contact lenses back in

•    If you need to use more than one type of eye medicine, the medicines must be used at least 5 minutes apart. Eye ointments should be used last.

•    If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor or pharmacist

How to use this medicine

•    Wash your hands

•    Remove the cap from the bottle

•    Tilt your head back

•    Squeeze one or two drops inside the lower lid without touching your eye

•    Close your eye

•    Wipe away any excess liquid from the eyes with a clean tissue

•    Always put the cap back on the bottle as soon as you have used it

•    Repeat in the other eye as needed How much to use

Adults, Elderly and Children aged 6 years and over

Seasonal allergic conjunctivitis:

•    One drop into each eye twice each day

•    This can be increased to four times each day if needed

•    Do not use for more than 12 weeks Vernal kerato-conjunctivitis

•    One drop into each eye four times each day

Adults and the Elderly only Perennial allergic conjunctivitis:

•    One drop into each eye twice each day

•    This can be increased to four times each day if needed

•    Use the drops regularly Children under 6 years

This medicine is not recommended for children aged less than 6 years.

If you take more Tilavist Eye Drops than you should

If you use more Tilavist than you should, talk to your doctor or go to a hospital straight away. Remember to take any medicine that is left with you so the doctor knows what you have taken.

If you forget to use Tilavist Eye Drops

If you forget a dose, use your drops as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose. Do not use a double dose to make up for a forgotten dose.

If you stop using Tilavist Eye Drops

Keep using the eye drops for as long as your doctor or pharmacist advises you. If you stop using Tilavist Eye drops too early, your allergy symptoms may come back.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

^4)    Possible side effects

Like all medicines, Tilavist Eye Drops can cause side effects, although not everybody gets them.

Stop using Tilavist Eye Drops and see a doctor as soon as possible if:

•    The itching, redness or swelling gets worse. You may be allergic to these drops

Talk to your doctor or pharmacist if any of the side effects gets serious or lasts longer than a few days, or if you notice any side effects not listed in this leaflet:

Common (affects 1 to 10 people in a 100)

•    Stinging or burning in your eyes or blurring of eyesight. This should only last for a short time and occurs immediately after using the eye drops

•    Change in the way things taste Uncommon (affects 1 to 10 people in a 1,000)

•    Mild eye irritation

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard By reporting side effects you can help provide more information on the safety of this medicine.

Eye drops should be kept in the original carton and not stored above 25°C and out of direct sunlight.

KEEP OUT OF THE SIGHT AND REACH OF CHILDREN

Avoid contamination of the contents by replacing the cap securely after use.

You must not use the eye drops after the expiry date. This is given in two places on the end flap of the carton and on the bottle label. In both places it is given as EXP followed by the month and year. The eye drops should not be used after the end of this month. Discard the eye drops four weeks after opening the first time.

Remember this medicine is for you. It can only be prescribed by a doctor. Never give your medicine to other people. It may harm them, even if their symptoms are the same as yours. This leaflet does not tell you everything about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist (chemist). He/she will have additional information about this medicine and will be able to advise you.

^ Further Information

What Tilavist Eye Drops contains

Contains nedocromil sodium 2% w/v.

Your medicine also contains the following inactive ingredients Benzalkonium chloride, sodium chloride, disodium edetate, and purified water.

The active ingredient belongs to a group of medicines known as anti-allergic / anti-inflammatory agents.

What Tilavist Eye Drops looks like and contents of the pack

This medicine is presented as a 5 ml sterile solution. Each ml of solution contains 20mg of nedocromil sodium, in a dropper bottle for administration to the eye.

Manufacturer and Licence Holder

The eye drops are manufactured by Sanofi Winthrop Industrie, Boulevard Industrial, Le Trait F-76580, France and procured from within the EU and repackaged by the Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE.

I POM PL 15184/1277

Leaflet revision date: 08/06/16

Tilavist is a registered trademark of Fisons Limited

Blind or partially sighted?

Is this leaflet hard to see or read? Phone Lexon (UK) Limited,

Tel: 01527 505414 for help.

®    Ref: 1277/080616/3/F

Nedocromil Sodium 2% w/v Eye Drops

(nedocromil sodium)

Patient Information Leaflet


Read all of this leaflet carefully before you start

using this medicine

•    Keep this leaflet. You may need to read it again.

•    If you have any further questions, ask your doctor or pharmacist.

•    This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.

•    If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. See section 4.

Your medicine is called Nedocromil Sodium 2% Eye

Drops but will be referred to as Nedocromil Sodium

Eye Drops through out this leaflet.

In this leaflet:

^ What nedocromil sodium Eye Drops are and what they are used for Before you use nedocromil sodium Eye Drops

[3) How to use nedocromil sodium Eye Drops

^ Possible side effects

^ How to store nedocromil sodium Eye Drops

,6 Further information

3 What Nedocromil sodium Eye Drops are and what they are used for

What nedocromil sodium Eye Drops are

Nedocromil sodium 2% Eye Drops (called Nedocromil sodium Eye Drops in this leaflet) contain a medicine called nedocromil sodium. This belongs to a group of medicines called anti-allergics.

How Nedocromil sodium Eye Drops work

It works by stopping the release of the natural substances in your eyes that can lead to an allergic reaction.

What Nedocromil sodium Eye Drops can be used for

Stopping, treating and relieving the symptoms of ‘allergic conjunctivitis' (inflammation of parts of the eye). Nedocromil sodium Eye Drops can be used for three types of allergic conjunctivitis:

•    ‘Perennial allergic conjunctivitis' in adults only: This type of allergy can happen at any time of the year and is often caused by animal fur or house dust mites. Signs include itchy, watery, red or inflamed eyes and puffy eyelids.

•    ‘Seasonal allergic conjunctivitis' in adults and children: This type of allergy, such as hay fever, can be caused by different pollens in different seasons of the year. Signs include itchy, watery, red or inflamed eyes and puffy eyelids.

•    ‘Vernal kerato conjunctivitis' in adults and children: This is a more severe type of allergy. Signs include bumps inside the upper eyelid, sensitivity to light and severe itching.

*2 Before you use Nedocromil sodium Eye Drops

Do not use this medicine and tell your doctor or pharmacist if:

• You are allergic (hypersensitive) to nedocromil sodium, or any of the other ingredients of Nedocromil sodium Eye Drops (listed in Section 6 below) Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue or around the eyes

Do not use this medicine if the above applies to you. If you are not sure, talk to your doctor or pharmacist before using Nedocromil sodium Eye Drops.

Take special care with Nedocromil sodium Eye Drops if:

• You wear soft contact lenses. You should not wear soft contact lenses while using these drops If you are not sure if this applies to you, talk to your doctor or pharmacist before using Nedocromil sodium Eye Drops.

Pregnancy and breast-feeding

Talk to your doctor before using this medicine if you are pregnant, might become pregnant or think you may be pregnant.

If you are breast-feeding or planning to breast-feed, talk to your doctor or pharmacist before taking or using any medicine.

Driving and using machines

Your eyesight may be affected after using this medicine. If this happens, do not drive or use any tools or machines until you can see clearly.

Important information about some of the ingredients of Nedocromil sodium Eye Drops

Nedocromil sodium Eye Drops contain benzalkonium chloride. This may cause your eyes to become irritated. It may also change the colour of your contact lenses.

How to use Nedocromil sodium Eye Drops

Always use Nedocromil sodium Eye Drops exactly as your doctor or pharmacist has told you. You should check with your doctor or pharmacist if you are not sure.

Using this medicine

•    If you wear hard or gas-permeable contact lenses, you should take them out while you use the eye drops. You should wait 15 minutes before you put the contact lenses back in

•    If you need to use more than one type of eye medicine, the medicines must be used at least 5 minutes apart. Eye ointments should be used last.

•    If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor or pharmacist

How to use this medicine

•    Wash your hands

•    Remove the cap from the bottle

•    Tilt your head back

•    Squeeze one or two drops inside the lower lid without touching your eye

•    Close your eye

•    Wipe away any excess liquid from the eyes with a clean tissue

•    Always put the cap back on the bottle as soon as you have used it

•    Repeat in the other eye as needed.

How much to use

Adults, Elderly and Children aged 6 years and over

Seasonal allergic conjunctivitis:

•    One drop into each eye twice each day

•    This can be increased to four times each day if needed

•    Do not use for more than 12 weeks Vernal kerato-conjunctivitis

•    One drop into each eye four times each day

Adults and the Elderly only Perennial allergic conjunctivitis:

•    One drop into each eye twice each day

•    This can be increased to four times each day if needed

•    Use the drops regularly Children under 6 years

This medicine is not recommended for children aged less than 6 years.

If you take more Tilavist Eye Drops than you should

If you use more Tilavist than you should, talk to your doctor or go to a hospital straight away. Remember to take any medicine that is left with you so the doctor knows what you have taken.

If you forget to use Nedocromil sodium Eye Drops

If you forget a dose, use your drops as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose. Do not use a double dose to make up for a forgotten dose.

If you stop using Nedocromil sodium Eye Drops

Keep using the eye drops for as long as your doctor or pharmacist advises you. If you stop using Nedocromil sodium Eye drops too early, your allergy symptoms may come back.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

^ Possible side effects

Like all medicines, Nedocromil sodium Eye Drops can cause side effects, although not everybody gets them.

Stop using Nedocromil sodium Eye Drops and see a doctor as soon as possible if:

•    The itching, redness or swelling gets worse. You may be allergic to these drops

Talk to your doctor or pharmacist if any of the side effects gets serious or lasts longer than a few days, or if you notice any side effects not listed in this leaflet:

Common (affects 1 to 10 people in a 100)

•    Stinging or burning in your eyes or blurring of eyesight. This should only last for a short time and occurs immediately after using the eye drops

•    Change in the way things taste Uncommon (affects 1 to 10 people in a 1,000)

•    Mild eye irritation

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard By reporting side effects you can help provide more information on the safety of this medicine.

Eye drops should be kept in the original carton and not stored above 25°C and out of direct sunlight.

KEEP OUT OF THE SIGHT AND REACH OF CHILDREN

Avoid contamination of the contents by replacing the cap securely after use.

You must not use the eye drops after the expiry date. This is given in two places on the end flap of the carton and on the bottle label. In both places it is given as EXP followed by the month and year. The eye drops should not be used after the end of this month. Discard the eye drops four weeks after opening the first time.

Remember this medicine is for you. It can only be prescribed by a doctor. Never give your medicine to other people. It may harm them, even if their symptoms are the same as yours. This leaflet does not tell you everything about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist (chemist). He/she will have additional information about this medicine and will be able to advise you.

Further Information

What Nedocromil sodium Eye Drops contain

Contains nedocromil sodium 2% w/v.

Your medicine also contains the following inactive ingredients

Benzalkonium chloride, sodium chloride, disodium edetate, and purified water.

The active ingredient belongs to a group of medicines known as anti-allergic / anti-inflammatory agents.

What Nedocromil sodium Eye Drops looks like and contents of the pack

This medicine is presented as a 5 ml sterile solution. Each ml of solution contains 20mg nedocromil sodium, in a dropper bottle for administration to the eye.

Manufacturer and Licence Holder

The eye drops are manufactured by Sanofi Winthrop Industrie, Boulevard Industrial, Le Trait F-76580, France and procured from within the EU and repackaged by the Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE.

POM| PL 15184/1277

Leaflet revision date: 08/06/16

Blind or partially sighted?

Is this leaflet hard to see or read? Phone Lexon (UK) Limited,

Tel: 01527 505414 for help.

Ref: 1277/080616/3/B